Pharmacological agonists for more-targeted CNS radio-pharmaceuticals
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چکیده
منابع مشابه
Pharmacological agonists for more-targeted CNS radio-pharmaceuticals
G-protein-coupled brain receptors provide abundant targets for psychotropic drugs and have been widely explored by PET (positron-emission tomography) brain imaging. PET is a nuclear medicine technique consisting in injecting molecules that have been radiolabeled with positron-emitters such as fluoride-18 or carbon-11. When such radiotracers can be implemented in animal models or humans, they ar...
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CNS activity It is patently obvious that CNS activity (and trans-cellular permeability in general) is a complex function of physical/chemical properties of molecules such as size, lipophilicity, hydrogen-bonding potential, charge, and conformation. For any given molecule, one of these factors may dominate others. Drugs with the brain as the site of action should, in general, be able to cross th...
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Traumatic injury or disease of the spinal cord and brain elicits multiple cellular and biochemical reactions that together cause or are associated with neuropathology. Specifically, injury or disease elicits acute infiltration and activation of immune cells, death of neurons and glia, mitochondrial dysfunction, and the secretion of substrates that inhibit axon regeneration. In some diseases, in...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.13418